Enzyme inhibition by allicin, the active principle of garlic
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منابع مشابه
Inhibition of streptolysin O by allicin - an active component of garlic.
Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated the effect of allicin and aqueous garlic extracts on the haemolytic activity of SLO. All tested materials potentially inhibited the SLO haemolytic activity. Allicin neutralized SLO in a dose- and ...
متن کاملAntimicrobial properties of allicin from garlic.
Allicin, one of the active principles of freshly crushed garlic homogenates, has a variety of antimicrobial activities. Allicin in its pure form was found to exhibit i) antibacterial activity against a wide range of Gram-negative and Gram-positive bacteria, including multidrug-resistant enterotoxicogenic strains of Escherichia coli; ii) antifungal activity, particularly against Candida albicans...
متن کاملMechanism-Based Studies of the Active Site-Directed Inhibition and Activation of Enzyme Transketolase
Derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (PDC). The inhibition of transketolase, a thiamine requiring enzyme such as PDF, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (MNPB) is reported here. These studies indicate that the inhibitor binds to the enzyme at the active site. A two-step inhibition was observed, first th...
متن کاملAntimalarial activity of allicin, a biologically active compound from garlic cloves.
The incidence of malaria is increasing, and there is an urgent need to identify new drug targets for both prophylaxis and chemotherapy. Potential new drug targets include Plasmodium proteases that play critical roles in the parasite life cycle. We have previously shown that the major surface protein of Plasmodium sporozoites, the circumsporozoite protein (CSP), is proteolytically processed by a...
متن کاملThe suspected medicinal value of garlic (Allium sativum L.) is now believed due to the properties of its active principle, allyithiosuffinicallyl ester, allicin (6). Allicin is produced by enzymatic degra
sativum L.) is now believed due to the properties of its active principle, allyithiosuffinicallyl ester, allicin (6). Allicin is produced by enzymatic degra dation of alum, S-allyl-frcysteine-S-oxide. Inhibi tion of sulfhydryl enzymes is associated with the presence of the —SO—S—grouping(11). The role of suffhydryl groups in cell division and mitoses has been reviewed by Barron (1) : an i...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1956
ISSN: 0306-3283
DOI: 10.1042/bj0630514